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Empirical antimicrobial guidelines are constantly evolving in response to laboratory susceptibility data. Broad spectrum agents exert a selection pressure gradually increasing antimicrobial resistance over time. In the level 3 neonatal intensive care unit (NICU), the majority of blood culture isolates are coagulase negative staphylococci (CoNS), which require appropriate empirical therapy. To assess antimicrobial resistance trends of CoNS and other commonly isolated organisms over a five year period in a busy neonatal unit.

Species Distribution and Susceptibilities of Bacteraemic Isolates from a United Kingdom Level 3 Neonatal Intensive Care Unit, a 5 Year Experience