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Summary The classical designs of bioreactors make it possible to realize optimum growth conditions for biological cultures by scalable controlling of the environmental factors. However the increasing complexity of these organisms or in vitro models requires a modern redesign and corresponding unique individual peripherals to simulate realistic living conditions and ensure a targeted operation. The challenge of this project is the up to today insufficient developed sensor or sensor arrays for the monitoring of reactions inside the microscaled bioreactor and on the other side to externally control these processes. The aim of this work is therefore the development and optimization of a human in vitro lymph node with integration of an in-line analytics as a disposable test system.

P3.5 - Development of a Multi-Sensor Micro Reactor System for cell-based analyses