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This paper describes a novel strategy to fabricate a low-cost microfluidic paper-based analytical device ( PAD) readily based on surface molecularly imprinted technology for clinical detection of carcino-embryonic antigen (CEA). The movable valve fabrication was realized using hollow rivets as the holding center to control the electrode and channel of the PAD in different layer movement, so the entire process of synthesis and testing could be completed easily. Graphene oxide, chitosan and CEA templates were assembled on the PAD as a substrate, and subsequently the molecularly imprinted membranes were formed by electropolymerization of dopamine. Finally, the novel PAD was obtained after removal of CEA templates. Because the entire manufacturing process was done on the PAD without any external treatment, the PAD has the characteristics of easy synthesis, low cost and low toxicity. Moreover, the PAD gave a flexible and easy way to operate the entire detection process conveniently. Experimental parameters such as equilibration time, scan cycles, template concentration and pH value were optimized. A good linearity was obtained in the range of 1 500 ng mL (R= 0.994) with the limit of detection (LOD) of 0.21 ng mL.

P1DH.2 - Paper-Based Microfluidic Analytical Device Based on Molecularly Imprinted Polymer for Detection of Carcinoembryonic Antigen