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The 2D-SPR system was applied to observe intracellular reactions of the cardiomyocyte differentiated from model stem cell upon the stimulation with various concentration of adrenaline. As expected, adrenaline response in cardiac differentiated cell regions increased in the concentratior range of 1-10 μM. The increase of reflected light intensity at 28 minutes after adrenaline stimulation was concentration dependent. Furthermore, we tried to monitor the closstalk of intracellular signal passways via αand βadrenoceptors which were expressed during cardiac differentiation. It was demonstrated that 2DSPR observeation of the cardiomyocyte response upon adrenaline stimulation was easy and useful for sensing of cardiac differentiated cells. And, we propose that this sensing system may be effective for consideration of the crosstalk in some intracellular signal transduction passways.

P1BS.14 - Adrenaline Sensing by 2D-SPR Observation of the Stem Cell-Induced Cardiac Cell Response