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Electrochemical technique has been widely applied in trace analysis on site due to high sensitivity, low detection limit, low time cost and simple instrumentation. Traditional electrochemical platform generally features drawbacks in limited channels, large size and complicated sensor calibration. This paper presents a multi-channel miniaturized electrochemical platform integrated with microfabricated electrodes and a microfluidic chip with serial and quantitative dilution. To implement serial and quantitative dilution on the microfluidic chip, the microfluidic structure was analogous to an electrical circuit and designed accordingly. The function of the designed structure was validated with COMSOL simulation. Microfabrication technique was used for fabrication of the microfluidic chip and electrode arrays. Four electrode arrays were patterned on a glass substrate to construct four independent electrochemical channels. This miniaturized electrochemical platform was implemented by bonding the microfluidic chip with the electrode arrays, and each channel can be independently used for different diluted samples measurement. This platform would provide the feasibility of high throughput electrochemical analysis and rapid sensor calibration with different diluted samples. The platform was tested in potassium ferricynide to validate the serial dilution functionality for electrochemical sensing.

HI.3 - Multi-channel miniaturized electrochemical platform based on microfluidics with serial and quantitative dilution