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In this study, a biomimetic taste receptor-based biosensor was developed using a multi-channel surface acoustic wave (SAW) device as transducers and bitter receptors as sensitive elements for chemical sensing. A DNA-directed immobilization method was employed to obtain high-efficient and controllable coupling between the sensitive area of multiple SAW devices and different bitter receptors. SAW device that is a mass-sensitive device was utilized to monitor the responses of a bitter receptor to its specific ligands. The measurement results show that this biosensor can record responsive signals of different bitter receptors when exposed to bitter substances by monitoring the changes in the phase shift of SAW devices. Each SAW detection channel can effectively record the responsive signals from the corresponding bitter receptors, which show good stability and anti-jamming ability. This biosensor can be used for the discrimination of different bitter substances due to the incorporation of multiple bitter receptors as sensitive elements. It is also applicable to the study of the interaction mechanisms between receptors and ligands.

AR2.5 - Multiple surface acoustic wave devices modified with different bitter receptors for chemical sensing