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In this study a novel low-cost method of amperometric sensors’ fabrication based on thick-film technique on solid support and their analytical application are presented. Complete graphite/silver cell sensors were fabricated with the new technology using a desk-top XYZ-dispensing robot and printing pastes. The amperometric sensors were applied for the detection of three selected tricyclic antidepressant drugs (TCAs): imipramine (IMI), amitriptyline (AMI) and doxepin (DOX). The monitoring of TAC concentration in patients’ body fluids is need, because these drugs can cause side or even toxic effect when overdosed. The possibility of simultaneous and individual amperometric determination of these compounds in media of different pH is demonstrated. The highest sensitivity was obtained for imipramine (213 nA/µM), while for doxepin and amitriptyline sensitivity was similar 32 and 34 nA/µM, respectively. Moreover, electrochemical determination of imipramine was characterized by the lowest potential of peak current (+0.77 V).

P2.1.5 A new Approach to Tricyclic Antidepressants Detection Based on Graphite Microsensors Fabricated by an Innovative Method