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Here we present a homemade system for highly sensitive measurements of cantilever sensor arrays. Two unique techniques developed by our group are utilized. Firstly, the expanded beam deflection (EBD) method that allows truly simultaneous measurements of multiple cantilevers with a simple optical apparatus consisting of a single and stationary laser beam, while providing the same sensitivity as the original optical beam deflection (OBD) method. Secondly, the real-time Brownian noise extraction technique allows combined static-dynamic mode operation in gaseous or liquid environment with no need for external excitation of vibrations. Thus constructed measurement system allows highly sensitive simultaneous measurement of bending as well as flexural and torsional vibrations of up to 8 cantilevers.

P2.1.20 Single-beam multi-cantilever optical measurement head for cantilever array-based biosensors