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This article presents our research concerning the synthesis of new thiophene-thiourea derivatives (1-12) and their pharmacological properties. These novel thiophene-thiourea derivatives were synthesized and characterized by IR, 1 H and 13 C NMR spectroscopy, mass spectrometry and elemental analysis. The crystal structure of N , N -diphenyl- N '-(thiophene-2-carbonyl)-thiourea was determined from single crystal X-ray diffraction data. It crystallizes in the monoclinic space group P 2 1 with unit cell dimensions of a =11.7469(5) A, b =6.0849(2) A, c=12.5792(6) A, β= 117.736(7) ° and V = 795.8(6) A 3 . The mass fragmentation pattern has also been discussed. The synthesized compounds were screened for their in vitro antifungal activities against the standard strains: C. Albicans , C. Glabrata , and C. Tropicalis . The compounds N -thiophene- N ', N '- bis (dimethyl-phosphinoylmethyl)thiourea, N -[(4-nitro-1 H -imidazol-2-yl)carbamothioyl]thiophene-2-carboxamide and N , N -diethyl- N '-(thiophene-2-carbonyl)-thiourea showed significant antifungal activities against microbial species.

Synthesis, spectroscopic characterization, crystal structure and pharmacological properties of some novel thiophene-thiourea core derivatives