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Synthesis of a series of 5‐aralkyl pyrrolidine‐3‐carboxylic acid derivatives namely, 1‐acetyl‐4‐ hydroxy‐5‐benzyl or 5‐(4‐alkoxy‐benzyl)‐pyrrolidine‐3‐carboxylic acids (3a‐e), 1‐H‐4‐ hydroxy‐5‐benzyl or 5‐(4‐alkoxy‐benzyl)‐pyrrolidine‐3‐carboxylic acids (4a‐e), 1‐acetyl‐5‐ benzyl or 5‐(4‐alkoxy‐benzyl)‐pyrrolidine‐3‐carboxylic acids (8a‐e), 1‐H‐5‐benzyl or 5‐(4‐ alkoxy‐benzyl)‐pyrrolidine‐3‐carboxylic acids (9a‐e) have been accomplished. The structures of the new compounds were assigned from IR, 1H NMR, 13C NMR and elemental analyses. Compounds 3a‐e, 4a‐e, 8a‐e and 9a‐e were biologically screened for their anticonvulsant potential using the subcutaneous pentylenetetrazole seizures (scPTZ) assay and Gabapentin as reference standard. The 1‐H‐4‐hydroxy‐5‐benzyl or 5‐(4‐alkoxy‐benzyl)‐pyrrolidine‐3‐ carboxylic acids (4a‐e) showed the highest anticonvulsant activity. Compound 4b was found to be the most potent one which exhibited 100% protection. Synthesis 5‐aralkyl pyrrolidine‐3‐carboxylic acids Epilepsy Anticonvulsants

Synthesis and preliminary biological screening of certain 5-aralkyl pyrrolidine-3-carboxylic acids as anticonvulsants