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Epithelial to Mesenchymal Transition (EMT) is an important phenomenon that is recently been recognized to play roles on prostate cancer metastasis through both epigenetic and biochemical signaling pathways. Using tissue engineering tools, we recreated a metastatic tumor niche to study the role of mir200 (a small RNA proven to reverse EMT processes) on extracellular matrix (ECM) fiber diameter guided prostate cancer cell EMT.

The impact of mir200 on extracellular matrix topography-guided epithelial-to-mesenchymal transition of prostate cancer cells