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I read the article titled “A Comparison of the Effects of 20% Mannitol and 3% NaCl on Coagulation Parameters In Vitro using ROTEM: A Prospective Randomized Crossover Study” by Ali et al. (1) with great interest. This study analysed the effects of mannitol, hypertonic saline (HS) and hydroxyethyl starch (HES) on coagulation. The methodology was meticulous, and it was designed to simulate clinical situations.

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Comment on: A Comparison of the Effects of 20% Mannitol and 3% NaCl on Coagulation Parameters In Vitro using ROTEM: A Prospective Randomized Crossover Study