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Objective: We aimed to investigate whether procalcitonin (PCT) is a useful biomarker for diagnosis of sarcoidosis and differentiate it from tuberculosis (TB). Methods: Thirty-five histopathologically-verified sarcoidosis pa tients with no previous treatment and 23 tuberculosis patients, who were diagnosed bacteriologically or histopathologically, were included in the study. Demographic data, clinical history, laboratory findings-serum procalcitonin (PCT) level, C-reactive protein (CRP), white blood cell (WBC) and erythrocyte sedimentation rate (ESR) and clinical findings were recorded. Results: Fifty-eight patients were included in the study. Twenty-three (39.7%) were male; 35 (60.3%) were female. Mean age was 42.6±14.1 and 47.9±15.9 years in sarcoidosis and TB groups respectively. Thirty-five (60.3%) had diagnoses of sarcoidosis and 23 (39.7%) TB. Of patients with TB; 15 were diagnosed via smear and culture while 8 were diagnosed via lymph node biopsies. Of patients with sarcoidosis; 20 were diagnosed with mediastinoscopy and 15 with transbronchial biopsies (TBB). There was no statistically significant difference for serum PCT level between sarcoidosis and tuberculosis (p=0.226). Additionally, PCT had no significant relationship with stages of sarcoidosis (p=0.873). Conclusion: We estabilished that PCT is not a reliable biomarker neither diagnose of sarcoidosis nor differentiate it from TB.

Procalcitonin: Is It a Useful Biomarker for Diagnosis and Differential Diagnosis of Sarcoidosis?