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The routine measurement of IgA anticardiolipin (aCL) and IgA anti-β 2 glycoprotein I (anti-β 2 GPI) antibodies remain controversial despite several studies demonstrating an association with thromboembolic disease in patients with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). This controversy may be a contributing factor for the current under use of IgA antiphospholipid antibodies. We aimed to investigate the nature of discrepant IgA anti-β 2 GPI reactivity to help define the diagnostic value of IgA antiphospholipid antibodies.

european journal of rheumatology :/european journal of rheumatology

Differential assay reactivity of immunglobulin A anti-ß2 glycoprotein I antibodies: implications for the clinical interpretation of antiphospholipid antibody testing