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1-As everyone knows, the systemic treatment paradigm of breast cancer pathobiology suggested by Bernard Fisher and his team has been obtained from thorough and cumbersome studies (by both experimental and randomized clinical trials) taking nearly 15 years. The theory of Halsted based on Virchow hypothesis is also represents a long and detailed clinical and laboratory experience. The third theory named ”Spectrum Theory” has been completely rejected by Fisher in 2010. Finally, 15 years have passed, and, it has not accepted as a new paradigm for management of breast cancer (2).

The Spectrum Theory in Breast Cancer Is Controversial