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Animal models of PD induced by the neurotoxin 6-hydroxydopamine (6OHDA) show locomotion and behavioral alterations mostly caused by the oxidative and inflammatory process induced by this neurotoxin. Sulfated agaran is a polysaccharide with sulfate groups found in the red seaweed Gracilaria cornea (SA). Recently, a study with SA showed anti-inflammatory effects and absence of toxic effects in vivo. The aim of this work was to evaluate the neuroprotective effects of SA after behavioral and locomotion alterations-induced by 6-OHDA intrastriatal injection in rats and to evaluate the safety of the intraestriatal administration of this polysaccharide in vivo. Methods: The seaweed was collected from Flecheiras beach, Brazil. SA was obtained as previously described by Coura et al (2012). Male Wistar rats (220-300 g) were randomically divided in eight groups (n=10 animals per group). Rats were anesthetized and treated with AS (15, 30 or 60 μg) alone or after 6-OHDA (20 μg) injection; 6-OHDA (20 μg) alone; or saline (sham group). All treatments were realized through stereotaxic injection into the right striatum and solutions were prepared diluted in saline (0.9%; with 0.01% ascorbic acid). Animals were maintained under ad libitum feeding conditions. This study was approved by the Ethics Committee for Animal Research of the Federal University of Ceará CEPA (no 45/13). The rats weight were measured daily for ponderal curve analysis. On the 14 day, rats were subjected to behavioral evaluation by the open-field test and the rotational test after apomorphine (3 mg/Kg). Results: The open-field test showed an increase (p<0.01) in the locomotor activity of the 6-OHDA+SA (30 and 60 μg) groups in 63.1±5.7 and 74.9±5.8 (numbers lines crossing), respectively, in relation to 6-OHDA group (47.4±3.7). 6-OHDA+SA (15, 30 or 60 μg) groups had the rotation number reduced (p<0.001) in 80, 83 and 91%, respectively, in comparison to 6-OHDA group. Additionally, rats submitted to intraestriatal SA injection (15, 30 or 60 μg) alone did not show statistical differences compared to the sham group in the overall tests utilized. Conclusions: SA from seaweed G. cornea show neuroprotective effects against locomotion disturbances induced by 6-OHDA injection into the striatum. SA did not show behavioral and ponderal changes in comparison to the sham group, suggesting safety.

NDD.06. Effects of a sulfated agaran from red seaweed Gracilaria cornea in 6-OHDA hemi-parkinsonian rats