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Studies of amino acid precursors has been gaining a lot of attention in recent years. This is due to the fact of being used in different areas , and have various applications. Its applications ranging from use as starting material in the synthesis of pharmaceuticals, cosmetics , herbicides , pesticides, among other applications and enzyme inhibitors. This study aimed to the synthesis of the amino acid precursor ethyl 2-N -acetyl3-5 -diphenyl -5oxo-pentanoate (NADPOPE ) and verification of their cytotoxic activity against the saline artemia and enzymatic inhibition of acetylcholinesterase. The synthesis of the precursor in study occurred through of the Michael reaction, that promotes the C-C link using phase transfer catalysis methods (PTC). The experimental procedures were accomplished in four steps: reaction between ethyl acetamidoacetato with chalcone under conditions PTC, treatment of the reaction mixture, purification and identification of the product obtained by 1H-Nuclear Magnetic Resonance. Subsequently the product was subjected to toxicity tests and inhibition of acetylcholinesterase. The results obtained in the tests analyzed and showed very significant, thus demonstrating characteristics very promising of the ethyl 2N-acetyl3-5 -diphenyl -5oxo-pentanoate as a potential enzyme inhibitor.

Síntese do precursor de aminoácido não natural 2-n-acetil-3,5-difenil-5-oxo-pentanoato de etila e teste para inibição da enzima acetilcolinesterase