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Compounds containing the –CO–N(R)–CO– function have shown a variety of important pharmacological properties, particularly acting as anticonvulsants. On the other hand, quinoline ring systems deserve special interest. We can also highlight that the class of five-membered heterocycles as oxazolidinones, pyrrolidin-2,5-diones and thiophenes derivatives attract considerable attention due to the broad range of pharmacological properties and their chemical applications. So, considering the great biological importance and employment of amino-heterocycles as starting material for the synthesis of new heterocycles, the purpose of this work is to report the results of an investigation of the chemical behavior of 7-amino-8-methylquinolines in side chain N-acylation and C-oxidation reactions.

New approach of side chain N-acylation and C-oxidation reactions of CF3-containing 7-amino-8-methylquinolines