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Cyclopeptides usually stand out due to their structural characteristics and their physico-chemical and biological properties of interest for use as therapeutic agents. 1 The increasing use of microreactors as a promising technology for the synthesis of compounds with pharmaceutical application and the absence of reports in the literature investigating the Ugi / Click reactions in cyclopeptide synthesis in continuous flow systems were the major motivations for this work.

Peptide and cyclopetide synthesis via Ugi and click reactions under microwave irradiation and in continuous flow system