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Multicomponent reactions in water are an important method in organic synthesis. One of the benefits of Green Chemistry is atom economy and safe solvent. Based on this some secondary and tertiary amine have been prepared in an aqueous medium in good yields. Wei and co-workers have obtained some propargylamines by coupling aldehydes, alkynes and amines in water in good yields. Aromatic amines are important building blocks for a broad range of biologically active compounds, and intermediate to dyes and pigments. In previous work, our group synthesized homoallylic amines from coupling reaction between secondary amines, methanal and halides in high yields. Herein we report the synthesis of aromatic amines in water with iminum from aniline and methanal.

Three-Component Coupling of Amines, Aldehydes and Aliphatic Halides Under Barbier-like Conditions in Water