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The metallation of aromatics is a convenient approach to the functionalization of unsaturated scaffolds 1 . Polyfunctional aryl halides are of high importance as agrochemicals, pharmaceuticals and building blocks 2 . Recently, mixed lithium/magnesium amides such as TMPMgCl.LiCl and TMP2Mg.2LiCl have proven to be interesting bases for functionalization of arenes under mild conditions 3 . In this work we wish to report the use of magnesium amides for the magnesiation of several haloaromatics oxazolines and subsequent reactions with electrophiles.

Directed Magnesiation of Haloaromatic Oxazolines using the mixed lithium/magnesium base TMPMgCl.LiCl