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Moreover, the rapid process optimization of synthetic steps on a small scale, combined with the telescoping of steps together in a continuous mode, enables more elaborate multistep sequences to be performed, leading directly to drug molecules or even natural products. 2 Bearing this in mind, we aimed at developing a continuous flow process for the synthesis of goniothalamin (3), which presents potent in vivo antitumor activity. 3

Integrated Batch and Continuous Flow Process for the Synthesis of Goniothalamin