English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

JP4-039 1 (scheme 1) is a novel nitroxide conjugate capable of crossing lipid bilayer membranes and scavenging reactive oxygen species (ROS) 1 . Only one synthesis is described in the literature, which consists of six steps and involves a one-pot hydrozirconation-transmetalation-addition 1 to a chiral sulfinimine as the key step. As our group has been recently exploiting the chemistry of α,β-unsaturated diazoketones 2–4 , we were interested in investigating these platforms for the direct synthesis of β,γunsaturated amides and apply the methodology to prepare the bioprotective agent JP4-039 in just one step from them.

A Two-Step Synthesis of the Bioprotective Agent JP4-039 from N-Boc-L-Leucinal.