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As part of a program aiming the synthesis of new compounds with anticancer and antiparasitic action, we recently synthesized aza-pterocarpans such as 1 and 2 (Figure 1). 1,2 Compound 1 showed significant activity against cancer cell lines and Leshimania. 1 In order to have more information on the structureactivity relationship in this new class of prototypes, we decided to prepare compounds type 3.

New Aza-pterocarpan Analogues by Intramolecular 1,3-Dipolar Cycloaddition in in situ generated nitroneolefins