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Lapachone derivatives are well known for their notable efficiency against many cancer cell lines.1 These compounds are virtually nonfluorescent, therefore a visual tracking to help in the elucidation of their mechanisms and targets inside the cell are a hard task. In order to surpass this major drawback, a naphthoquinone derivative were joint together with a BTD (2,1,3-benzothiadiazole) core, already known for its photoluminescent properties,2 affording a fluorescent compound that could be tracked inside the cell (Scheme 1).

Benzothiadiazole-triazole-linked biologically active lapachone derivatives: Antitumoral activity and bioimaging application