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The ability to efficiently hydrolyze nucleic acids in a biomimetic non-destructive process with high selectivity has become important because one can find many applications in structural design of new probes and drug development. This molecular recognition is a common feature in biological systems, where some functional groups form supramolecular systems by non-covalent interactions. For example, the guanidinium group present in the active site of the Staphylococcus nuclease is used to recognize the phosphodiester group, accelerating its hydrolysis. 1

Studies toward the synthesis of potencial artificial nucleases derived from trypargine