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The synthesis of optically pure cyanohydrins is an area of growing interest in synthetic chemistry 1 . Microwave irradiation has also attracted considerable interest in recent years because of their advantages, such as reduced chemical reaction time, reduced side reactions, increased yields and improved reproducibility 2 . The objective of this study was investigate the kinetic resolution of (±)mandelonitrile (1) using lipase from Candida antarctica under microwave irradiation and conventional conditions.

Influence of microwave irradiation on lipase-catalyzed kinetic resolution of (±)-mandelonitrile