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Benzodiazepines (BDZ) derivatives constituted the first pharmacological entity coined with the term privileged structure, due to their large number of therapeutic and pharmacological properties 1,2 . Besides the well-known Nervous Central System related properties (ansiolytic, hypnotic and anticonvulsant, among others), they had been found also useful as antibiotic, antiviral (HIV-1), antitumor or cardiovascular drugs 1 . In the other hand 1,5benzodiazepine moiety had been much less studied than 1,4-benzodiazepines counterparts. In this work, it is reported the synthesis, characterization and antimicrobiological evaluation of different 4-aryl-4,5-dihydro-1H-1,5-benzodiazepin2-ol derivatives.

Synthesis and antimicrobial evaluation of 4-aryl-4,5-dihydro- 1H-1,5-benzodiazepin-2-ol derivatives