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The chiral drug (RS)-2-(4-(2-methylpropyl)phenyl) propanoic acid, known as ibuprofen, is an important non-steroidal anti-inflammatory drug, also notorious for its analgesic and antipyretic properties. This medicine is market in racemic form R-(-)-ibuprofen and S-(+)-ibuprofen, however, in some countries only the second enantiomer is applied. This paper refers to the study of the thermodynamic parameters relative for separation of the racemic mixture in analytical chiral chromatographic columns packed with cellulose tris (3,5-dimethylphenylcarbamate). In this analysis, the enthalpy (ΔH 0 ), entropy (ΔS 0 ), enthalpy difference (ΔΔH 0 ), entropy difference (ΔΔS 0 ), and isoenantioselective temperature (Tiso) was determined by van’t Hoff approach.

Thermodynamic study of the separation of racemic ibuprofen by chiral liquid chromatography