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The present study was approved to investigate the effects of thyroid dysfunctions were induced in female albino rats on thyroid gland and ovary, in the case of hyperthyroidism we used Levothyroxine (LVX), and in case of hypothyroidism we used Carbimazole (CBZ), Then measure hormonal levels of thyroid and examine the histological changes of thyroid gland and ovary. Uses for this study forty albino female rats aged twenty weeks old and weighed between 200-300g were separated randomly into four groups: Group I was administration orally 100 μg/kg b.w. of LVX for three months. Group II was administration orally 5mg/kg/ b.w. of CBZ for three months while Group III was orally administration 1ml of normal saline only (0.09%) as a control group for three months. Group IV has orally administration a mix of 50 μg/kilogram for the bodyweight of LVX for six weeks+2.5 mg/kilogram for the bodyweight of CBZ for six weeks. Finally, all the animals were scarified and then blood collection, thyroid, and ovary samples were taken. Physiological study contain thyroid hormones levels measured by using the Enzyme-Linked Immunosorbent Assay (ELISA) kit, we showed significantly (p < 0.01) increase levels of Triiodothyronine (T3), Tetraiodothyronine (T4), in contrast decrease levels of thyroid-stimulating hormone (TSH) levels in Group I treated with LVX while group observed significantly (p < 0.01) decrease in levels of (T4), (T3), while TSH level increase. The fourth group, showed a slight increase in the levels of thyroid hormones. The results of histological study revealed that, Group I an increase in the colloid resorption with vacuolation of the nuclei of epithelial cells that lining the follicles of the thyroid; formation of corpus luteum in ovarian tissue with the presence of one secondary follicle in Group II. Group III showed a decrease in the colloid resorption with formation of multiple ovarian cysts and hemorrhagic cysts while the histological changes in Group IV showed active thyroid follicles with the presence of resorption vacuoles and congestion blood vessels and formation of many primordial follicles and primary antral follicles of ovarian tissue.

HISTOLOGICAL AND PHYSIOLOGICAL STUDY OF THYROID DYSFUNCTIONS ON OVARY IN FEMALE RATS (RATTUS RATTUS)