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In the present study, the mean differences of some parameters according to study groups including (Control group, diabetic rats, diabetic rats with Nano silymarin, Nano silymarin and Diabetic rats with extract of silymarin) were studied. The mean of diabetic rats groups with Nano silymarin was more decrease in sugar (mg/dl) when compared with diabetic rats groups, while when compared diabetic rats groups with extract silymarin, the mean was less decrease than groups with Nano silymarin. The mean of insulin in diabetic rats groups with Nano silymarin was increased when compared with diabetic rats groups, while when compared diabetic rats groups with extract silymarin, the mean was no effected with groups diabetic rats treated with Nano silymarin. The mean of IGF in diabetic rats groups with Nano silymarin was decreased when compared with diabetic rats groups, while when compared diabetic rats groups with extract silymarin, the mean was more decrease than groups with Nano silymarin. The mean of HOMA Insulin resistance in diabetic rats groups with Nano silymarin was decreased when compared with diabetic rats groups, while when compared diabetic rats groups with extract silymarin, the mean was more decrease than groups with Nano silymarin. The mean of protein in diabetic rats groups with Nano silymarin was not effected when compared with diabetic rats groups, also when compared diabetic rats groups with extract silymarin, the mean was not affected. However, there was significant differences between means of albumin according to study group. The mean of cholesterol and Triglyceride in diabetic rats groups with Nano silymarin was decreased when compared with diabeticrats groups, while when compared diabetic rats groups with extract silymarin, the mean was mild decrease than groups with Nano silymarin. High density lipoprotein (HDL) in diabetic rats groups with Nano silymarin was increased when compared with diabetic rats groups, while when compared diabetic rats groups with extract silymarin, the mean was mild increasedthan groups with Nano silymarin. In addition, low density lipoprotein (LDL) and very low density lipoprotein (VLDL) in diabetic rats groups with Nano silymarin was decreased when compared with diabetic rats groups, while when compared diabetic rats groups with extract silymarin, the mean was mild decreased than groups with Nano silymarin. This study aims to compare between Silybum marianum extract and Nanoparticles activity in treatment of diabetes mellitus.

TREATMENT OF INDUCED DIABETES IN RATS BY NANOSILYMARIN