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This study aimed to know the protective role of Cichorium intybus root aqueous extract in inhibiting the formation of kidney stones induced by ethylene glycol in male Oryctolagus cumiculus, expressed by monitoring kidney function and studying the effect of oxidative stress induced by ethylene glycol, as well as by microscopic examination of kidney tissue. In this study, male domestic rabbits used Oryctolag cuniculus with (20) animals whose ages ranged from (6-8) months and were examined by a veterinarian and their weights ranged between (1500 + 100) gm. The animals were divided into four experimental groups by 5 rabbits / Group, dosed for 60 days, as follows: The first group was given water and food throughout the trial period, The second group dosed (50 mg / kg of body weight) with Cichorium intybus root aqueous extract, while the third group was dosed with ethylene glycol at a concentration of (0.9%) mL / kg of body weight, and the fourth group was dosed with ethylene glycol in addition to Cichorium intybus root aqueous extract. The results showed that the formation of stones induced by ethylene glycol in male white rabbits led to negative effects in the biochemical variables, represented by a significant increase at a probability level (P≤ 0.05) in in total protein, urea, creatinine and K ion, and treatment with this substance did not lead to a change in albumin. And Mg ion and Ca ion, while the treatment with E.g led to a decrease in the occurrence of histological changes and calcium crystal deposition were evident in the kidneys. The results of the group treated with Cichorium intybus root aqueous extract at a concentration (50 mg / kg of body weight) showed a significant increase, Mg, and did not affect, albumin, and a decrease in creatine, total protein, and urea. Ca compared with the control group, while no tissue changes occurred to the kidneys. The treatment with Cichorium intybus root aqueous extract and the treatment with ethylene glycol at a concentration of (0.9%) led to a decrease in Ca, K, creatinine, total protein, urea, albumin and a significant increase in, Mg, to a group Control treated with ethylene glycol, and this treatment led to a significant improvement in kidney tissue.

plant archives/plant archives

THE PROTECTIVE ROLE OF AQUEOUS EXTRACT OF PLANT ROOTS CICHORIUM INTYBUS L. IN A NUMBER OF BIOCHEMICAL VARIABLES IN THE BLOOD SERUM AND TISSUES OF RABBITS INFECTED WITH EXPERIMENTAL KIDNEY STONES