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Increased global obesity prevalence is a serious issue as it causes several other chronic metabolic disorders, including diabetes mellitus, one of the major global pandemics a few days ago. Obesity increases the propensity by several folds to develop insulin resistance and type 2 diabetes mellitus (T2DM). Our aim was to investigate the hypoglycemic, hypolipidemic and hepatoprotective activities of Bombax Ceiba extract on the biochemical and histological evaluation in obese rats fed High-carbohydrate high-fat diets (HCHFD) to prevent of metabolic diseases that cause obesity. Sixty male rats were divided randomly (12 rats/ group) into 5 experimental groups. First (control) group: 12 rats were fed with standard diet. 2 group (Bombax) rats were fed on standard diet and Bombax ceiba extract (400 mg/kg body weight) was administrated daily orally. The third group (HCHFD), rats were fed on HCHF diet whereas rats in the fourth group Bombax + HCHFD (Prophylactic) rats fed on standard diet and take Bombax ceiba extract (400 mg/kg body weight orally daily for 8 weeks then fed on HCHF diet and take Bombax ceiba extract to the end of experiment. Fifth group HCHF + Bombax (Treatment) rats were also fed on HCHF diet then take Bombax ceiba extract (400 mg/kg body weight daily). The experiment period was 20 weeks. Blood glucose, insulin, HOMA-IR, lipid profile, aspartate aminotransferase (AST), alanine aminotransferase (ALT), adropin,interleukin-6 (IL-6), retinol binding protein-4 (RBP-4), salusin-α and salusin-β were measured. Also histopathology for aorta tissue was done. Our findings have shown significant increases in glucose, HOMA-IR, cholesterol, triglycerides, AST, ALT, IL-6, RBP-4 and salusin-β levels with significant decrease in insulin, high density lipoprotein (HDL), adropin and salusinα, in HCHFD group in comparison with the control group,these findings improved in prophylactic and treated groups after treatment with Bombax ceiba extractin compare to HCHFD group. Our study concluded that Bombax ceiba extract has potential hypoglycemic, hypolipidemic and hepatoprotective activities on the prevention of metabolic diseases resulting in rats fed HCHF diet and the histological evaluation confirm our biochemical results.

ANTIDIABETIC AND HEPATOPROTECTIVE ACTIVITIES OF BOMBAX CEIBA EXTRACT IN OBESE RATS WITH METABOLIC SYNDROME