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The current study was designated to investigate the effect of pumpkin aqueous extract on blood glucose and wound healing in diabetic-wounded rats. Forty male rats were divided into five groups (8rat for each). G1 : served as healthy control, G2 : Positive control, wounded and diabetic rats , G3: Wounded and diabetic rats treated with aqueous extract 200 mg\kg b.wt. , G4: Wounded and diabetic rats treated with aqueous extract 200 mg\kg b.wt. and wounds treated locally with aqueous extract 200 mg\kg b.wt. as ointment ( mix with inert Vaseline) and G5: healthy(non-diabetic) rats, wound treated locally with aqueous extract 200 mg\kg b.wt. The effects of aqueous extract on some parameters were investigated in normal and diabetic rats such as glucose level, tumor necrosis factor alpha (TNF-α), platelets derived growth factor (PDGF) ,total and differential count of W.B.C. The results investigated a significant( P≤0.05) decrease in blood glucose level in all treated diabetic groups compare with positive groups on 8th day and an improvement healing in wounds in rats after 8 days of treatment with plant extract, the level of TNF-α and PDGF were significantly (P<0.05) increased in the positive control group and other diabetic groups as compared with negative control on the 4 day ,then it showed decrease in all treated groups as compared with positive control group on the 8th day, total count of WBC showed asignificant increase in the positive control group and other diabetic groups as compared with negative control on the 4 day ,then it showed decrease in all treated groups except the positive control group on the 8th day. The percentage of neutrophils and platelets reported a significant (P<0.05) increase in the positive control and other treated groups on the 4th day as compared with the negative control group on 8th day. Moreover, the statistical analysis relaved a significant (P≤0.05) increase in the percentage of lymphocyte on the 4th and 8th day in positive and other treated groups compared with control groups at the same period. Keyword: Pumpkin, blood glucose, aqueous extract.

STUDY THE PHYSIOLOGICAL AND IMMUNOLOGICAL EFFECTS OF PUMPKIN EXTRACT ON WOUND HEALING IN DIABETIC RATS