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The natural killer (NK) cells role has been investigated in the therapy of many cancer types and in breast cancer but little information is known about the effect of chemotherapy on circulating CD56 marker of NK cells in plasma of chemotherapy patients. A total of 24 plasma sample of breast cancer patients were compared with 24 plasma sample of apparently healthy control, the CD56 concentration was detected by Elabscience ELISA kit from Elabscience. The demographic data revealed the mean±SD age of breast cancer cases was 51.16±8.91. The mean±SD of CD56 concentration for breast cancer patients and apparently healthy control was 72.76±30.5, 53.19±12.66 respectively. There were significant differences between patients and control at probability P = 0.0057. The level of NK cells was elevated in breast cancer patients compared to the control group due to chemotherapy which increase the proliferation of these cells to overcome cancer.

DETECTION OF CIRCULATING NK CELLS IN BREAST CANCER PATIENTS UNDER CHEMOTHERAPY IN AL HILLAH CITY, IRAQ