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Research Problem Statement   Premenstrual dysphoric disorder (PMDD) is a severe form of premenstrual syndrome (PMS) that involves a combination of emotional and physical symptoms that result in significant functional impairment. PMDD can be debilitating and there are multiple treatment options available, but these are not without side effects. Although complimentary or alternative medicine may be beneficial in treating PMDD, however, there is not enough data available to validate their effectiveness. This study aimed at comparing and determining the efficacy of a homoeopathic mother tincture complex (Vitex agnus castus, Melissa officinalis and Valeriana officinalis) compared to placebo in the management of PMDD.  Methodology   A sample size of 30 consenting female participants with PMDD who met the inclusion criteria as set out in the Diagnostic and Statistical Manual of Mental Disorders. The duration of the study was three months for each participant. Participants were randomly divided into experimental and placebo groups with three consultations over the study period where Kessler Psychological Distress Scale and Visual Analogue Scale were applied. Non-parametric and inferential analysis of data were performed to analyse and compare the effects of treatment and time on symptoms over the three consultation periods (α.05).  Results   Results for both scales showed no statistical significance in the interaction between time and treatment. The results showed no statistical differences between the control and  experimental group in the management of PMDD. However, the mean value measured in the experimental group were consistently lower than the control.  Conclusion   The conclusion derived from this study is that the homoeopathic complex studied is not effective in the treatment of PMDD. None of the results showed significant differences between the treatment and the placebo group trials. Further studies are highly recommended in this field.

The efficacy of a homoeopathic mother tincture complex (Vitex agnus castus, Melissa officinalis and Valeriana officinalis) in the management of premenstrual dysphoric disorder