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Gliomas may rarely arise in the leptomeninges without any evidence of intraaxialinvolvement. A case of primary diffuse leptomeningeal gliomatosis (PDLG)histologically diagnosed as oligoastrocytoma is presented. A 50-year-old womanpresented with nausea, vomiting and headache. Magnetic resonance imaging (MRI)of cranium and cervical region revealed dural thickening starting from thecraniocervical junction to the level of C4 without any parenchymal lesions. CSFexamination showed an increase in protein and decrease in glucose levels. Therewere neither any kind of atypical cells nor any kind of growth in bacterialcultures. The patient underwent biopsy at the level of C1 for diagnosis. Thespecimen was diagnosed as primary diffuse leptomeningeal gliomatosis, withphenotypic features of astrocytoma and oligodendroglioma.

A case of primary diffuse leptomeningeal gliomatosis predominantly involving the cervical spinal cord and mimicking chronic meningitis