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.   1970   80%     5   15~20%.  Cortes (1)  Jaffe (2)Doxorubicin Methotrexate , Cisplatin, Ifosfamide, Cyclophosphamide   5   70~80% . 1970    80%          90%      ,          .              ,  Limb Salvage with Low and Heat Treated Autobone