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The purpose of this study was to determine theconcordance between two equations used for estimating glomerular filtration rate, in order to verify the possibility to be used interchangeably in the clinical practice. The two equations are of Cockcroft & Gault (CG) (1976) formula and MDRD (modification of Diet in Renal Disease) (1999) formula, these two models allow the assessment of glomerular filtration rate (GFR) by calculating creatinine clearance (CL CR).To make a comparison between these two formulas different models were examined forSubjects with normal renal function, Patients with renal impairment, Diabetic patients, Age and sex, finally lean and obese patients by modeling two algorithms withthe two functions. Results show that the formula of Cockcroft & Gault remains the method of choice for e stimating renal function in clinical practice.

Modeling Algorithm of Estimation of Renal Function by the Cockcroft and Mdrd Formulas