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To explore the mechanism of oxidative stress in the development of prostate cancer, here we compared 4-hydroxynonenal (4-HNE)- treated LNCaP (hormone-sensitive) and DU145 (hormone insensitive) cells with significant differences in sensitivity to androgen.

Comparison of 4-hydroxynonenal induced p53-mediated apoptosis in prostate cancer cells LNCaP and DU145