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Despite many years of experience and numerous studies, lupus nephritis (LN) management still remains a challenge for clinicians. The choice of diagnostic procedures and subsequent optimal therapy in the population of patients with LN is crucial to achieve remission. Renal biopsy has an important role in the diagnostic process at the beginning of the disease, and its performance at diagnosis of LN is not a subject of controversy. However, the performance of biopsy in a subsequent renal flare or after maintenance treatment is not common.

Repeat renal biopsy in lupus nephritis – unnecessary harm and risk of complications or important diagnostic tool with clinical consequences?