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Summary Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) is a newly identified syndrome dealing with pathological effects of adjuvant use. In recent years observations have shown that a num ber of clinical situations displaying similar features can be associated with an overactive immune response and with the inflammatory effect of adjuvants administration. Chronic stimulation of the immune sys tem by substances used as adjuvants may lead to the occurrence of numerous symptoms such as chronic fatigue, arthritis, myalgia, cog nitive impairment and neurological disorders. The aim of this article is to present how and why adjuvants – while allegedly causing no specific immune response – may become a cause of development of autoimmune diseases. Streszczenie

Autoimmune/inflammatory syndrome induced by adjuvants – a new diagnostic problem or the solution of a diagnostic riddle