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Objective: The aim of the study was to visualize lymphatic capillaries (LC) in synovial membrane obtained during synovectomy from patients with rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA). Material and methods: Specialized inter-endothelial junctions (e.g. endothelial microvalves) were visualized under both a transmission electron microscope (Figs. 1a, b) and light microscope (Figs. 1c, d). These openable junctions enable trafficking of immune cells and drainage of surplus tissue fluid from the interstitium of connective tissue in synovial membrane into prenodal lymph and play a substantial role in the drainage function of LC in synovial joints. Results: Lymphocytes, macrophages and some debris were found in lumens of LC under the light microscope (Fig. 2). Numerous infiltrates of immune cells in the interstitium of synovial membrane located predominantly around postcapillary venules and in the vicinity of LC (Fig. 3) were observed. Conclusion: The role of endothelial microvalves in drainage of inflammatory infiltrates into lymphatic capillaries deserves further investigation. S t r e s z c z e n i e

Oryginal paper Oedema, infiltration and drainage of connective tissue in rheumatoid arthritis – a preliminary report