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Several studies implicated altered inflammatory response in the susceptibility to ovarian cancer, and polymorphisms in inflammatory cytokines were shown to play an important role in the development of malignancies, including ovarian cancer (OC). Here we investigated the relationship between polymorphisms in IL-1 β (-511C&gt;T), IL-1RN VNTR, TNF- α (-308G&gt;A), and TNF RII (-322 VNTR) and OC risk in Tunisian women.

Common variants in IL-1RN, IL-1β and TNF-α and the risk of ovarian cancer: a case control study