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the aim of this prospective study is to define markers that can be used in the diagnosis and follow-up of patients with endometriosis by determining serum CA 125, transforming growth factor β1 (tgF-β1), interleukin 6 (il-6), and il-12 levels. the study group consisted of 14 patients diagnosed to have mild to moderate peritoneal endometriosis, 47 patients with ovarian endometrioma during laparoscopy and 12 healthy patients as a control group. Serum CA 125, tgF-β1, il-6, and il-12 levels were evaluated using eliSA kits. Serum CA 125 levels were significantly higher in the endometrioma group when compared to the control group (p < 0.001) and mild to moderate peritoneal endometriosis group (p < 0.001). mean serum tgF-β1 levels were significantly higher in the endometrioma group when compared to the mild to moderate peritoneal endometriosis group (p < 0.001). in addition, serum tgF-β1 levels were found to be significantly different with regard to the stage of the endometriosis. Serum il-6 levels were significantly higher in the endometrioma group compared to the endometriosis group (p = 0.024) and control group (p = 0.05). mean serum il-12 levels were lower in patients with endometriosis. in conclusion; tgF-β1 and il-6 measurements might be a promising alternative in adjunct to CA 125 for the non-invasive diagnosis of endometrioma. however CA 125, tgF-β1, il-6 and il-12 seem not to have the diagnostic value in the diagnosis of early stage endometriosis. of all the serum markers studied, only tgF-β1 was found to be correlated with the stage of endometriosis.

Serum cytokine and growth factor levels in patients with endometriosis