English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

To investigate the inhibitory action of different doses of tripterygium hypoglaucum hutch (THH) on the expression of hypoxia-inducible factor-1 α(HIF-1 α) in collagen II-induced arthritis (CIA) rat model. Material and methods: CIA rat model was established. Rats were randomly divided into five groups. Rats in the treatment group were received high, moderate or low doses of THH for 30 ds, and drugs administered by gastrogavage. Morphological changes of ankle joints and arthritis index (AI) were observed. HIF-1 αexpression was examined by RT-PCR and immunohistochemical staining technique. Results: THH inhibited joint swelling and destruction in CIA, significantly reduced the volume of paw and arthritis index, suppressed HIF-1 αexpression and synovial membrane's proliferation in CIA. Conclusions: The results showed that THH had a good therapeutic effect on CIA rats. The mecha nism that HTT treatment RA may correlate with regulation of hypoxia inducible factor-1 αHIF-1 αexpres sion in both peripheral blood and synovial tissue.

central-european journal of immunology/central european journal of immunology

Experimental immunology Inhibitory action of different doses of tripterygium hypoglaucum hutch on expression of hypoxia inducible factor-1α in collagen Ⅱ-induced arthritis rat model