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In this paper a Petri net based model of the process of endothelial dysfunction is presented. The model describes some selected aspects of this process and their relation with atherosclerosis. Models expressed in the language of Petri net theory have, on the one hand, an intuitive graphical interpretation, and on the other hand, they can be analyzed using rigorous mathematical methods. Such analysis and simulation of the net behavior can be supported by many freely available software tools. Here, results of an analysis based on t-invariants of the proposed model are presented. In particular, feasible t-invariants, MCT-sets and t-clusters have been calculated and their biological meaning has been determined.

biotechnologia

RESEARCH PAPER Selected aspects of endothelial dysfunction and their influence on the atherosclerosis process modeled and analyzed by Petri net based approach