English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Biotechnology is the field to yield modern systems, tools, and materials by taking control at the atomic and molecular levels using the features that appear on those surfaces. Applications for biotechnology in medical diagnostics, food, medicine, environment, energy, chemistry, physics, etc, introduce this technology as an interdisciplinary and cross-sectoral context. Tiliroside (kaempferol 3-O-(600-O-p-coumaroyl)-b-D glucopyranoside) is a glycosidic flavonoid found in several medicinal and dietary sources, such as linden, rose hips and strawberries. In recent years, plant extracts have been identified as a new way to discover new anti-diabetic drugs. Due to the unwanted side effects associated with current drugs, an increasing number of patients are demanding to use natural products with anti-diabetic activity.    Material and methods  The biological activities of tiliroside against human aldose reductase were investigated using a molecular docking study. In the oncological part of the recent study, the treated cells with tiliroside were assessed by MTT ‎assay for 48h about the cytotoxicity and anti-liver cancer ‎ properties on normal (HUVEC) and ‎liver cancer ‎ cell lines, i.e. SNU-387, LMH/2A, McA-RH7777, and N1-S1 Fudr.‎    Results  The results of these calculations revealed the high affinity of this compound to the enzyme. This binding affinity could be considered as a reason for the low IC50 of tiliroside against the aldose reductase.    Conclusions  Tiliroside can be utilized as an efficient drug in the treatment of cancer in humans.

Tiliroside: Anti-liver cancer effects and investigation of aldose ‎reductase inhibition properties with molecular modeling studies