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The clitoris is partially responsible for sexual arousal. The integrity of the extracellular matrix is essential for clitoral erection. Sexual dysfunction is a phenomenon associated with age.    Material and methods  The clitoris of cadavers of 20- to 80-year-old women was excised and histologically processed. Stereological analysis was performed to quantify the volumetric density of collagen, elastic fibers, and smooth muscle.    Results  A significant increase in collagen and a decrease in smooth muscle and elastic fibers were observed in older women.    Conclusions  In short, these changes caused by aging could contribute to female sexual dysfunction concerning clitoral orgasm.

Changes in the extracellular matrix of the clitoris caused by aging: a stereological and comparative study