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The aim of this study was to investigate the effects of glabridin on vascular inflammation and vascular remodeling of the left anteriordescending artery (LAD) in diabetic rat heart.    Material and methods  Eighty male Wistar rats were divided into five groups:(1) control rats; (2) glabridin control rats that received diet supplementedwith glabridin (CGB); (3) diabetic rats (STZ); (4) diabetic rats that receiveda supplemented with glabridin (STZ + GB) 40 mg/kg BW; and (5) diabeticrats treated with glyburide (STZ + GR) 4 mg/kg BW. Diabetic animals wererendered diabetic by injection of a single dose (60 mg/kg BW) of streptozotocin (STZ). After 8 weeks, the biochemical markers of oxidative stress wereassessed. The three-dimensional morphology of LAD was examined by vascular corrosion casting. Enzyme-linked immunosorbent assay was appliedto determine the expression of TNF-α and IL-1β proteins. Western blot andimmunofluorescence analysis were used to detect the expression of VEGFand TGF-β1 secretions.    Results  The lumen diameter of the LAD was notably smaller and stenotic.LAD analysis revealed arterial notch and evolved irregular caliber. Moreover,neovascularization appeared and was extensive. The Trolox equivalent antioxidant capacities and Trolox equivalent antioxidant capacity levels of hearttissue were significantly decreased and levels of malondialdehyde werefound to be elevated in STZ rats whereas they were improved in the STZ+ GB group. Increased expression levels of VEGF, TGF-β1, TNF-α, and IL-1βproteins in heart tissues were observed in the STZ group. The inflammationcytokine levels were decreased in the STZ + GB group.    Conclusions  These results revealed that glabridin was able to reduce LADand heart tissue damage. Glabridin can be an antioxidant and can reduce thepathology of the LAD in terms of reducing inflammation and restoring condition of the LAD. It would be beneficial in examining the role of glabridin asa therapeutic aim in diabetes treatment research in coronary artery disease.

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Glabridin from licorice alleviates vascular inflammation and promotes vascular remodeling of the left anterior descending coronary artery in diabetic rat heart